The PhD thesis will focus on the relationship between ageing and age-related macular degeneration and encompass the full breadth of scientific work, including the development and implementation of study protocols, coordination and supervision of data collection, and data analysis and publication. The project will leverage data from the Rhineland Study, a deeply-phenotyped, large-scale population-based cohort study. Available data include comprehensive multi-omics data, including (epi)genomics, transcriptomics, metabolomics, lipidomics, and proteomics; eye imaging data, advanced MRI data as well as extensive behavioral and clinical data, including cognitive and neurological assessments, cardiovascular assessments, medical history, and medication use. The study currently includes over 14,000 individuals, of whom more than 6,000 already have longitudinal data.
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