CAAN's current scientific priorities include: (1) tracking autonomic trajectories from age 20–60 and identifying their causes and consequences, including a first-of-its-kind longitudinal study with CSF biomarker collection and longitudinal LC imaging; (2) randomized clinical trials of breathing-based interventions (e.g., slow breathing, 4-7-8 breathing) to test causal roles of autonomic activity on emotion, brain, and cognition; (3) advancing brainstem imaging methods; and (4) understanding brain mechanisms of emotion–cognition interactions in aging. * Integrating polysomnography into CAAN studies: Design and implement standard operating procedures for overnight ambulatory and/or in-lab polysomnography across CAAN's longitudinal study and clinical trials, including montage selection (EEG, EOG, EMG, ECG, respiratory effort, airflow, oximetry, body position); lead vendor and ...
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