DZNE is a world-leading, internationally oriented center for cutting-edge research into diseases of the nervous system. Within this framework, this PhD project will specifically aim to identify (epi)genetic and proteomic determinants of glymphatic system function and white matter pathology, contributing to a deeper understanding of sCVD and brain aging. The Rhineland Study includes comprehensive multi-omics data, including (epi)genomics, transcriptomics, metabolomics, lipidomics, and proteomics, advanced MRI data, as well as extensive behavioral and clinical data, including cognitive and neurological assessments, cardiovascular and anthropometric assessments, sensory systems tests, medical history, and medication use. * Statistical knowledge and experience with R programming
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