The predominant methods applied will be genetic analysis (Targeted Next Generation Sequencing, Copy number variation analysis), modification of candidate genes (CRISPR/Cas9-system, retro- or lentiviral expression of putative oncogenes, RNAi-mediated KnockDown of putative tumorsuppressor genes), analysis of RNA- (RNA- Seq, qPCR) and protein-expression (Western Blot) and fuctional analysis using established cell culture systems to evaluate cell viability, proliferation, apoptosis induction, cell cycle, migration, angiogenesis and colony- forming abilities. Further tasks include independent evaluation and integration of experimental data and presentation of data on international congresses.